Ontology highlight
ABSTRACT:
SUBMITTER: de Araujo ED
PROVIDER: S-EPMC6895964 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
de Araujo Elvin D ED Orlova Anna A Neubauer Heidi A HA Bajusz Dávid D Seo Hyuk-Soo HS Dhe-Paganon Sirano S Keserű György M GM Moriggl Richard R Gunning Patrick T PT
Cancers 20191108 11
Src Homology 2 (SH2) domains arose within metazoan signaling pathways and are involved in protein regulation of multiple pleiotropic cascades. In signal transducer and activator of transcription (STAT) proteins, SH2 domain interactions are critical for molecular activation and nuclear accumulation of phosphorylated STAT dimers to drive transcription. Sequencing analysis of patient samples has revealed the SH2 domain as a hotspot in the mutational landscape of STAT proteins although the functiona ...[more]