Ontology highlight
ABSTRACT:
SUBMITTER: Shankaraiah RC
PROVIDER: S-EPMC6895981 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Shankaraiah Ram C RC Gramantieri Laura L Fornari Francesca F Sabbioni Silvia S Callegari Elisa E Negrini Massimo M
Cancers 20191114 11
Hepatocellular carcinoma (HCC) is a deadly disease and therapeutic efficacy in advanced HCC is limited. Since progression of chronic liver disease to HCC involves a long latency period of a few decades, a significant window of therapeutic opportunities exists for prevention of HCC and improve patient prognosis. Nonetheless, there has been no clinical advancement in instituting HCC chemopreventive strategies. Some of the major challenges are heterogenous genetic aberrations of HCC, significant mo ...[more]