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Animal Models of Hepatocellular Carcinoma Prevention.


ABSTRACT: Hepatocellular carcinoma (HCC) is a deadly disease and therapeutic efficacy in advanced HCC is limited. Since progression of chronic liver disease to HCC involves a long latency period of a few decades, a significant window of therapeutic opportunities exists for prevention of HCC and improve patient prognosis. Nonetheless, there has been no clinical advancement in instituting HCC chemopreventive strategies. Some of the major challenges are heterogenous genetic aberrations of HCC, significant modulation of tumor microenvironment and incomplete understanding of HCC tumorigenesis. To this end, animal models of HCC are valuable tools to evaluate biology of tumor initiation and progression with specific insight into molecular and genetic mechanisms involved. In this review, we describe various animal models of HCC that facilitate effective ways to study therapeutic prevention strategies that have translational potential to be evaluated in a clinical context.

SUBMITTER: Shankaraiah RC 

PROVIDER: S-EPMC6895981 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Animal Models of Hepatocellular Carcinoma Prevention.

Shankaraiah Ram C RC   Gramantieri Laura L   Fornari Francesca F   Sabbioni Silvia S   Callegari Elisa E   Negrini Massimo M  

Cancers 20191114 11


Hepatocellular carcinoma (HCC) is a deadly disease and therapeutic efficacy in advanced HCC is limited. Since progression of chronic liver disease to HCC involves a long latency period of a few decades, a significant window of therapeutic opportunities exists for prevention of HCC and improve patient prognosis. Nonetheless, there has been no clinical advancement in instituting HCC chemopreventive strategies. Some of the major challenges are heterogenous genetic aberrations of HCC, significant mo  ...[more]

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