Ontology highlight
ABSTRACT:
SUBMITTER: Sergeeva O
PROVIDER: S-EPMC6896045 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Sergeeva Olga O Kepe Vladimir V Zhang Yifan Y Miller-Atkins Galen A GA Keynon Jonathan D JD Iyer Renuka R Sexton Sandra S Awadallah Amad A Xin Wei W Saunthararajah Yogen Y Chan E Ricky ER Lee Zhenghong Z
Cancers 20191107 11
Clinical diagnosis of hepatocellular carcinoma (HCC) relies heavily on radiological imaging. However, information pertaining to liver cancer treatment such as the proliferation status is lacking. Imaging tumor proliferation can be valuable in patient management. This study investigated <sup>18</sup>F-labeled clofarabine ([<sup>18</sup>F]CFA) targeting deoxycytidine kinase (dCK) for PET imaging of dCK-dependent proliferation in HCC. Since clinical PET scans showed a high liver background uptake o ...[more]