Systematic Review of Irreversible Electroporation Role in Management of Locally Advanced Pancreatic Cancer.

ABSTRACT: Ablative techniques provide in patients with locally advanced pancreatic cancer (LAPC) symptomatic relief, survival benefit and potential downsizing. Irreversible Electroporation (IRE) represents potentially an ideal solution as no thermal tissue damage occurs. The purpose of this review is to present an overview on safety, feasibility, oncological results, survival and quality of life improvement obtained by IRE. A systematic search was performed in PubMed, regarding the use of IRE on PC in humans for studies published in English up to March 2019. 15 original studies embodying 691 patients with unresectable LAPC who underwent IRE were included. As emerged, IRE works better on tumour sizes between 3-4 cm. Oncological results are promising: median OS from diagnosis or treatment up to 27 mon

SUBMITTER: Lafranceschina S 

PROVIDER: S-EPMC6896066 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature