Ontology highlight
ABSTRACT:
SUBMITTER: Gasior-Perczak D
PROVIDER: S-EPMC6896084 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Gąsior-Perczak Danuta D Kowalik Artur A Walczyk Agnieszka A Siołek Monika M Gruszczyński Krzysztof K Pałyga Iwona I Mikina Estera E Trybek Tomasz T Kopczyński Janusz J Mężyk Ryszard R Góźdź Stanisław S Kowalska Aldona A
Cancers 20191107 11
<i>BRAF</i><sup>V600E</sup> is the most common somatic mutation in papillary thyroid carcinoma (PTC) and the majority of evidence indicates that it is associated with an aggressive clinical course. Germline mutations of the <i>CHEK2</i> gene impair the DNA damage repair process and increase the risk of PTC. Coexistence of both mutations is expected to be associated with poorer clinical course. We evaluated the prevalence of concomitant <i>CHEK2</i> and <i>BRAF</i><sup>V600E</sup> mutations and t ...[more]