Ontology highlight
ABSTRACT:
SUBMITTER: Wojnarowicz PM
PROVIDER: S-EPMC6896334 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Wojnarowicz Paulina M PM Lima E Silva Raquel R Ohnaka Masayuki M Lee Sang Bae SB Chin Yvette Y Kulukian Anita A Chang Sung-Hee SH Desai Bina B Garcia Escolano Marta M Shah Riddhi R Garcia-Cao Marta M Xu Sijia S Kadam Rashmi R Goldgur Yehuda Y Miller Meredith A MA Ouerfelli Ouathek O Yang Guangli G Arakawa Tsutomu T Albanese Steven K SK Garland William A WA Stoller Glenn G Chaudhary Jaideep J Norton Larry L Soni Rajesh Kumar RK Philip John J Hendrickson Ronald C RC Iavarone Antonio A Dannenberg Andrew J AJ Chodera John D JD Pavletich Nikola N Lasorella Anna A Campochiaro Peter A PA Benezra Robert R
Cell reports 20191001 1
Id helix-loop-helix (HLH) proteins (Id1-4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states. Id proteins are primarily expressed during development to inhibit differentiation, but they become re-expressed in adult tissues in diseases of the vasculature and cancer. We show that the genetic loss of Id1/Id3 reduces ocular neovascularization in mouse models of wet age-related macular degeneration (AMD) and retino ...[more]