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Host Competency of the Multimammate Rat Mastomys natalensis Demonstrated by Prolonged Spirochetemias with the African Relapsing Fever Spirochete Borrelia crocidurae.


ABSTRACT: African multimammate rats, Mastomys natalensis, are widely distributed in sub-Saharan Africa and live in close association with humans. In West Africa, numerous field studies have shown these animals may be naturally infected with the relapsing fever spirochete Borrelia crocidurae, the primary cause of tick-borne relapsing fever in this region of the continent. However, naturally infected individual rats have never been examined over time; therefore, the true host competency of these rats for this spirochete is unknown. Therefore, using animals from an established laboratory colony of M. natalensis, rats were experimentally infected with B. crocidurae and their blood examined to 28 days postinoculation. These animals were highly susceptible to infection and displayed prolonged and cyclic spirochetemias. Our results demonstrate these peridomestic rodents are likely competent hosts for infecting argasid tick vectors and play a primary role in the enzootic cycle for B. crocidurae in West Africa.

SUBMITTER: Boardman K 

PROVIDER: S-EPMC6896849 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Host Competency of the Multimammate Rat <i>Mastomys natalensis</i> Demonstrated by Prolonged Spirochetemias with the African Relapsing Fever Spirochete <i>Borrelia crocidurae</i>.

Boardman Kristin K   Rosenke Kyle K   Safronetz David D   Feldmann Heinz H   Schwan Tom G TG  

The American journal of tropical medicine and hygiene 20191201 6


African multimammate rats, <i>Mastomys natalensis</i>, are widely distributed in sub-Saharan Africa and live in close association with humans. In West Africa, numerous field studies have shown these animals may be naturally infected with the relapsing fever spirochete <i>Borrelia crocidurae</i>, the primary cause of tick-borne relapsing fever in this region of the continent. However, naturally infected individual rats have never been examined over time; therefore, the true host competency of the  ...[more]

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