Ontology highlight
ABSTRACT:
SUBMITTER: Bowman CE
PROVIDER: S-EPMC6896898 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Bowman Caitlyn E CE Selen Alpergin Ebru S ES Cavagnini Kyle K Smith Danielle M DM Scafidi Susanna S Wolfgang Michael J MJ
Cell reports 20191001 5
The extreme metabolic demands of pregnancy require coordinated metabolic adaptations between mother and fetus to balance fetal growth and maternal health with nutrient availability. To determine maternal and fetal contributions to metabolic flexibility during gestation, pregnant mice with genetic impairments in mitochondrial carbohydrate and/or lipid metabolism were subjected to nutrient deprivation. The maternal fasting response initiates a fetal liver transcriptional program marked by upregula ...[more]