Ontology highlight
ABSTRACT:
SUBMITTER: Shen E
PROVIDER: S-EPMC6897316 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Shen Erxia E Rabe Hardis H Luo Lin L Wang Lei L Wang Qin Q Yin Jie J Yang Xueying X Liu Wenquan W Sido Jessica M JM Nakagawa Hidetoshi H Ao Lin L Kim Hye-Jung HJ Cantor Harvey H Leavenworth Jianmei W JW
Cell reports 20191101 7
Follicular regulatory T (T<sub>FR</sub>) cells are a specialized suppressive subset that controls the germinal center (GC) response and maintains humoral self-tolerance. The mechanisms that maintain T<sub>FR</sub> lineage identity and suppressive activity remain largely unknown. Here, we show that expression of Blimp1 by FoxP3<sup>+</sup> T<sub>FR</sub> cells is essential for T<sub>FR</sub> lineage stability, entry into the GC, and expression of regulatory activity. Deletion of Blimp1 in T<sub>F ...[more]