Ontology highlight
ABSTRACT:
SUBMITTER: Martin B
PROVIDER: S-EPMC6897890 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Martin Brian B Gabris Beth B Barakat Amr F AF Henry Brian L BL Giannini Marianna M Reddy Rajiv P RP Wang Xuewen X Romero Guillermo G Salama Guy G
Scientific reports 20191206 1
Healthy aging results in cardiac structural and electrical remodeling that increases susceptibility to cardiovascular diseases. Relaxin, an insulin-like hormone, suppresses atrial fibrillation, inflammation and fibrosis in aged rats but the mechanisms-of-action are unknown. Here we show that relaxin treatment of aged rats reverses pathological electrical remodeling (increasing Nav1.5 expression and localization of Connexin43 to intercalated disks) by activating canonical Wnt signaling. In isolat ...[more]