Ontology highlight
ABSTRACT:
SUBMITTER: Vehik K
PROVIDER: S-EPMC6898786 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Vehik Kendra K Lynch Kristian F KF Wong Matthew C MC Tian Xiangjun X Ross Matthew C MC Gibbs Richard A RA Ajami Nadim J NJ Petrosino Joseph F JF Rewers Marian M Toppari Jorma J Ziegler Anette G AG She Jin-Xiong JX Lernmark Ake A Akolkar Beena B Hagopian William A WA Schatz Desmond A DA Krischer Jeffrey P JP Hyöty Heikki H Lloyd Richard E RE
Nature medicine 20191202 12
Viruses are implicated in autoimmune destruction of pancreatic islet β cells, which results in insulin deficiency and type 1 diabetes (T1D)<sup>1-4</sup>. Certain enteroviruses can infect β cells in vitro<sup>5</sup>, have been detected in the pancreatic islets of patients with T1D<sup>6</sup> and have shown an association with T1D in meta-analyses<sup>4</sup>. However, establishing consistency in findings across studies has proven difficult. Obstacles to convincingly linking RNA viruses to isle ...[more]