Ontology highlight
ABSTRACT:
SUBMITTER: Gurevich DB
PROVIDER: S-EPMC6899018 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Gurevich David B DB French Kathryn E KE Collin John D JD Cross Stephen J SJ Martin Paul P
Journal of cell science 20190926 5
Implanting biomaterials in tissues leads to inflammation and a foreign body response (FBR), which can result in rejection. Here, we live image the FBR triggered by surgical suture implantation in a translucent zebrafish model and compare with an acute wound response. We observe inflammation extending from the suture margins, correlating with subsequent avascular and fibrotic encapsulation zones: sutures that induce more inflammation result in increased zones of avascularity and fibrosis. Moreove ...[more]