Ontology highlight
ABSTRACT:
SUBMITTER: Horowitz LB
PROVIDER: S-EPMC6899041 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Horowitz Lauren Bayer LB Brandt Julia P JP Ringstad Niels N
Development (Cambridge, England) 20191119 22
Nervous system development is instructed by genetic programs and refined by distinct mechanisms that couple neural activity to gene expression. How these processes are integrated remains poorly understood. Here, we report that the regulated release of insulin-like peptides (ILPs) during development of the <i>Caenorhabditis elegans</i> nervous system accomplishes such an integration. We find that the p38 MAP kinase PMK-3, which is required for the differentiation of chemosensory BAG neurons, limi ...[more]