Unknown

Dataset Information

0

Comparison of Solifenacin and Bilateral Apical Fixation in the Treatment of Mixed and Urgency Urinary Incontinence in Women: URGE 1 Study, A Randomized Clinical Trial.


ABSTRACT: BACKGROUND:The aetiology of urgency urinary incontinence is a matter of debate. Current treatment options are based on the hypothesis of a neurological disorder of bladder innervation. However, it has also been hypothesised that one main cause is the reduced function of the bladder-holding apparatus, that is, insufficient suspension of the vesico-urethral junction. This study compared the effects of surgical apical vaginal elevation with those of solifenacin on urgency urinary incontinence in women. PATIENTS AND METHODS:Women with mixed and urgency urinary incontinence were randomised to either an established pharmacological arm (10 mg/day solifenacin) or the surgical arm (bilateral uterosacral ligament replacement, cervicosacropexy, CESA; or vaginosacropexy, VASA. Clinical and objective outcomes were assessed at 4 months after each type of intervention. RESULTS:The study was terminated early; 55 patients were operated on and 41 patients received pharmacological treatment. After surgical treatment, 23 patients (42%, 95% confidence intervaI=29-55%) became continent compared to four patients (10%, 95% confidence intervaI=1-19%) during solifenacin treatment. CONCLUSION:Compared to pharmacological treatment, the surgical repair of the apical vaginal end restored urinary continence in significantly more patients.

SUBMITTER: Ludwig S 

PROVIDER: S-EPMC6899101 | biostudies-literature | 2019 Nov-Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Comparison of Solifenacin and Bilateral Apical Fixation in the Treatment of Mixed and Urgency Urinary Incontinence in Women: URGE 1 Study, A Randomized Clinical Trial.

Ludwig Sebastian S   Becker Ingrid I   Mallmann Peter P   Jäger Wolfram W  

In vivo (Athens, Greece) 20191101 6


<h4>Background</h4>The aetiology of urgency urinary incontinence is a matter of debate. Current treatment options are based on the hypothesis of a neurological disorder of bladder innervation. However, it has also been hypothesised that one main cause is the reduced function of the bladder-holding apparatus, that is, insufficient suspension of the vesico-urethral junction. This study compared the effects of surgical apical vaginal elevation with those of solifenacin on urgency urinary incontinen  ...[more]

Similar Datasets

| S-EPMC7076894 | biostudies-literature
| S-EPMC4128900 | biostudies-literature
| S-EPMC4439377 | biostudies-literature
| S-EPMC8056293 | biostudies-literature
| S-EPMC3384992 | biostudies-literature
| S-EPMC4161260 | biostudies-literature
| S-EPMC4556587 | biostudies-literature
| S-EPMC6469490 | biostudies-literature
| S-EPMC2267872 | biostudies-literature
| S-EPMC4141945 | biostudies-literature