Ontology highlight
ABSTRACT:
SUBMITTER: Yang Z
PROVIDER: S-EPMC6899201 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Yang Zhi Z Wang Haoqing H Liu Albert Z AZ Gristick Harry B HB Bjorkman Pamela J PJ
Nature structural & molecular biology 20191202 12
The human immunodeficiency virus (HIV-1) envelope (Env) glycoprotein, a (gp120-gp41)<sub>3</sub> trimer, mediates fusion of viral and host cell membranes after gp120 binding to host receptor CD4. Receptor binding triggers conformational changes allowing coreceptor (CCR5) recognition through CCR5's tyrosine-sulfated amino (N) terminus, release of the gp41 fusion peptide and fusion. We present 3.3 Å and 3.5 Å cryo-EM structures of E51, a tyrosine-sulfated coreceptor-mimicking antibody, complexed w ...[more]