Genetic alteration patterns and clinical outcomes of elderly and secondary acute myeloid leukemia.
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ABSTRACT:
SUBMITTER: Wang SY
PROVIDER: S-EPMC6899678 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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Genetic alteration patterns and clinical outcomes of elderly and secondary acute myeloid leukemia.
Wang Shi-Yang SY Cheng Wen-Yan WY Mao Yuan-Fei YF Zhu Yong-Mei YM Liu Fu-Jia FJ Ma Ting-Ting TT Shen Yang Y
Hematological oncology 20190820 4
To illustrate the clinical and genetic features of elderly and secondary acute myeloid leukemia (AML) patients, we compared 145 elderly AML (e-AML) and 55 secondary AML (s-AML) patients with 451 young de novo AML patients. Both e-AML and s-AML patients showed lower white blood cell (WBC) and bone marrow (BM) blasts at diagnosis. NPM1, DNMT3A, and IDH2 mutations were more common while biallelic CEBPA and IDH1 mutations were less seen in e-AML patients. s-AML patients carried a higher frequency of ...[more]
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