Ontology highlight
ABSTRACT:
SUBMITTER: Vondrak K
PROVIDER: S-EPMC6900073 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Vondrak Karel K Parisi Francesco F Dhawan Anil A Grenda Ryszard R Webb Nicholas J A NJA Marks Stephen D SD Debray Dominique D Holt Richard C L RCL Lachaux Alain A Kelly Deirdre D Kazeem Gbenga G Undre Nasrullah N
Clinical transplantation 20190919 10
<h4>Background and aims</h4>This multicenter trial compared immediate-release tacrolimus (IR-T) vs prolonged-release tacrolimus (PR-T) in de novo kidney, liver, and heart transplant recipients aged <16 years. Each formulation had similar pharmacokinetic (PK) profiles. Follow-up efficacy and safety results are reported herein.<h4>Materials and methods</h4>Patients, randomized 1:1, received once-daily, PR-T or twice-daily, IR-T within 4 days of surgery. After a 4-week PK assessment, patients conti ...[more]