Ontology highlight
ABSTRACT:
SUBMITTER: Jandl K
PROVIDER: S-EPMC6900182 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Jandl Katharina K Thekkekara Puthenparampil Helene H Marsh Leigh M LM Hoffmann Julia J Wilhelm Jochen J Veith Christine C Sinn Katharina K Klepetko Walter W Olschewski Horst H Olschewski Andrea A Brock Matthias M Kwapiszewska Grazyna G
The Journal of pathology 20190116 3
In idiopathic pulmonary arterial hypertension (IPAH), global transcriptional changes induce a smooth muscle cell phenotype characterised by excessive proliferation, migration, and apoptosis resistance. Long non-coding RNAs (lncRNAs) are key regulators of cellular function. Using a compartment-specific transcriptional profiling approach, we sought to investigate the link between transcriptional reprogramming by lncRNAs and the maladaptive smooth muscle cell phenotype in IPAH. Transcriptional prof ...[more]