Ontology highlight
ABSTRACT:
SUBMITTER: Ko HR
PROVIDER: S-EPMC6900500 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Ko Hyo Rim HR Hwang Inwoo I Jin Eun-Ju EJ Yun Taegwan T Ryu Dongryeol D Kang Jong-Sun JS Park Kye Won KW Shin Joo-Ho JH Cho Sung-Woo SW Lee Kyung-Hoon KH Ye Keqiang K Ahn Jee-Yin JY
Proceedings of the National Academy of Sciences of the United States of America 20191120 49
ErbB3-binding protein 1 (EBP1) is implicated in diverse cellular functions, including apoptosis, cell proliferation, and differentiation. Here, by generating genetic inactivation of <i>Ebp1</i> mice, we identified the physiological roles of EBP1 in vivo. Loss of <i>Ebp1</i> in mice caused aberrant organogenesis, including brain malformation, and death between E13.5 and 15.5 owing to severe hemorrhages, with massive apoptosis and cessation of cell proliferation. Specific ablation of Ebp1 in neuro ...[more]