Ontology highlight
ABSTRACT:
SUBMITTER: Galardini M
PROVIDER: S-EPMC6901017 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Galardini Marco M Busby Bede P BP Vieitez Cristina C Dunham Alistair S AS Typas Athanasios A Beltrao Pedro P
Molecular systems biology 20191201 12
Loss-of-function (LoF) mutations associated with disease do not manifest equally in different individuals. The impact of the genetic background on the consequences of LoF mutations remains poorly characterized. Here, we systematically assessed the changes in gene deletion phenotypes for 3,786 gene knockouts in four Saccharomyces cerevisiae strains and 38 conditions. We observed 18.5% of deletion phenotypes changing between pairs of strains on average with a small fraction conserved in all four s ...[more]