Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in children.

ABSTRACT: Objective:This in situ study compared the effectiveness of two toothpastes containing hydroxyapatite or 500?ppm fluoride in promoting remineralization and inhibiting caries development. Materials and methods:Two enamel blocks (human primary teeth), one sound and one with artificially-produced caries lesion, were exposed to toothpaste containing either 10% hydroxyapatite or 500?ppm F- (amine fluoride) via intra-oral appliance worn by 30 adults in two-arm double blind randomized crossover study lasting 14 days per arm (ClinicalTrials.gov: NCT03681340). Baseline and post-test mineral loss and lesion depth (LD) were quantified using microradiography. One-sided t-test of one group mean was used for intragroup comparison (baseline vs. post-test), while two-sided t-test of two independent means was used to compare the two toothpaste groups. Results:Pairwise comparison (baseline vs. test) indicated significant (p?

SUBMITTER: Amaechi BT 

PROVIDER: S-EPMC6901576 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature