Ontology highlight
ABSTRACT:
SUBMITTER: Coggins SA
PROVIDER: S-EPMC6901729 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Coggins Si'Ana A SA Holler Jessica M JM Kimata Jason T JT Kim Dong-Hyun DH Schinazi Raymond F RF Kim Baek B
Virology 20190814
Unlike HIV-1, HIV-2 and some SIV strains replicate at high dNTP concentrations even in macrophages due to their accessory proteins, Vpx or Vpr, that target SAMHD1 dNTPase for proteasomal degradation. We previously reported that HIV-1 reverse transcriptase (RT) efficiently synthesizes DNA even at low dNTP concentrations because HIV-1 RT displays faster pre-steady state k<sub>pol</sub> values than SAMHD1 counteracting lentiviral RTs. Here, since the k<sub>pol</sub> step consists of two sequential ...[more]