Ontology highlight
ABSTRACT:
SUBMITTER: Lederer S
PROVIDER: S-EPMC6901947 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Lederer Simone S Dijkstra Tjeerd M H TMH Heskes Tom T
Frontiers in pharmacology 20191126
In synergy studies, one focuses on compound combinations that promise a synergistic or antagonistic effect. With the help of high-throughput techniques, a huge amount of compound combinations can be screened and filtered for suitable candidates for a more detailed analysis. Those promising candidates are chosen based on the deviance between a measured response and an expected non-interactive response. A non-interactive response is based on a principle of no interaction, such as Loewe Additivity ...[more]