Ontology highlight
ABSTRACT:
SUBMITTER: Gaur V
PROVIDER: S-EPMC6902002 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Gaur Vineet V Ziajko Weronika W Nirwal Shivlee S Szlachcic Aleksandra A Gapińska Marta M Nowotny Marcin M
Nucleic acids research 20191201 22
Structure-selective endonucleases cleave branched DNA substrates. Slx1 is unique among structure-selective nucleases because it can cleave all branched DNA structures at multiple sites near the branch point. The mechanism behind this broad range of activity is unknown. The present study structurally and biochemically investigated fungal Slx1 to define a new protein interface that binds the non-cleaved arm of branched DNAs. The DNA arm bound at this new site was positioned at a sharp angle relati ...[more]