Ontology highlight
ABSTRACT:
SUBMITTER: Mardenborough YSN
PROVIDER: S-EPMC6902014 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Mardenborough Yannicka S N YSN Nitsenko Katerina K Laffeber Charlie C Duboc Camille C Sahin Enes E Quessada-Vial Audrey A Winterwerp Herrie H K HHK Sixma Titia K TK Kanaar Roland R Friedhoff Peter P Strick Terence R TR Lebbink Joyce H G JHG
Nucleic acids research 20191201 22
DNA mismatch repair (MMR) maintains genome stability through repair of DNA replication errors. In Escherichia coli, initiation of MMR involves recognition of the mismatch by MutS, recruitment of MutL, activation of endonuclease MutH and DNA strand incision at a hemimethylated GATC site. Here, we studied the mechanism of communication that couples mismatch recognition to daughter strand incision. We investigated the effect of catalytically-deficient Cas9 as well as stalled RNA polymerase as roadb ...[more]