Ontology highlight
ABSTRACT:
SUBMITTER: Rockey DC
PROVIDER: S-EPMC6902116 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Rockey Don C DC Du Qinghong Q Weymouth Nathaniel D ND Shi Zengdun Z
The American journal of pathology 20190830 11
In the liver, smooth muscle α-actin (SM α-actin) is up-regulated in hepatic stellate cells (HSCs) as they transition to myofibroblasts during liver injury and the wound healing response. Whether SM α-actin has specific functional effects on cellular effectors of fibrosis such as HSC is controversial. Here, the relationship between SM α-actin and type 1 collagen expression (COL1A1), a major extracellular matrix protein important in liver fibrosis, is investigated with the results demonstrating th ...[more]