Ontology highlight
ABSTRACT:
SUBMITTER: Kambayashi Y
PROVIDER: S-EPMC6902253 | biostudies-literature | 2019 Sep-Dec
REPOSITORIES: biostudies-literature
Kambayashi Yumi Y Fujimura Taku T Ohuchi Kentaro K Tono Hisayuki H Ishida Yoshihiro Y Otsuka Atsushi A Aiba Setsuya S
Case reports in oncology 20190901 3
Patients with invasive extramammary Paget's disease have an increased risk of secondary malignancy, mostly occurring colorectal carcinoma. TP53 is a regulator of apoptosis, cell cycle arrest, and DNA damage response pathways, and has been reported as one of the genetic biomarkers for colorectal carcinoma. In this report, we describe a case of advanced invasive EMPD concomitant with cecal cancer with a rare variant of TP53 single nucleotide polymorphism (rs121912665). To our knowledge, there is n ...[more]