Association of Receiving Multiple, Concurrent Fracture-Associated Drugs With Hip Fracture Risk.

ABSTRACT:

Importance

Many prescription drugs increase fracture risk, which raises concern for patients receiving 2 or more such drugs concurrently. Logic suggests that risk will increase with each additional drug, but the risk of taking multiple fracture-associated drugs (FADs) is unknown.

Objective

To estimate hip fracture risk associated with concurrent exposure to multiple FADs.

Design, setting, and participants

This cohort study used a 20% random sample of Medicare fee-for-service administrative data for age-eligible Medicare beneficiaries from 2004 to 2014. Sex-stratified Cox regression models estimated hip fracture risk associated with current receipt of 1, 2, or 3 or more of 21 FADs and, separately, risk associated with each FAD and 2-way FAD combination vs no FADs. Mode

SUBMITTER: Emeny RT 

PROVIDER: S-EPMC6902800 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature