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Genetics, Cell Biology, and Pathophysiology of Pancreatitis.

ABSTRACT: Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis, pancreatic genetics has made rapid progress. The identification of mutations in genes involved in the digestive protease-antiprotease pathway has lent additional support to the notion that pancreatitis is a disease of autodigestion. Clinical and experimental observations have provided compelling evidence that premature intrapancreatic activation of digestive proteases is critical in pancreatitis onset. However, disease course and severity are mostly governed by inflammatory cells that drive local and systemic immune responses. In this article, we review the genetics, cell biology, and immunology of pancreatitis with a focus on protease activation pathways and other early events.

SUBMITTER: Mayerle J

PROVIDER: S-EPMC6903413 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Genetics, Cell Biology, and Pathophysiology of Pancreatitis.

Mayerle Julia J Sendler Matthias M Sendler Matthias M Hegyi Eszter E Beyer Georg G Lerch Markus M MM Sahin-Tóth Miklós M

Gastroenterology 20190118 7

Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis, pancreatic genetics has made rapid progress. The identification of mutations in genes involved in the digestive protease-antiprotease pathway has lent additional support to the notion that pancreatitis is a disease of autodigestion. Clinical and experimental observations have provided compelling evidence that premature intrapancreatic activation of digestive proteases is critical in pancreatitis onset ...[more]

PMID: 30660731

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