Ontology highlight
ABSTRACT:
SUBMITTER: Mayerle J
PROVIDER: S-EPMC6903413 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Gastroenterology 20190118 7
Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis, pancreatic genetics has made rapid progress. The identification of mutations in genes involved in the digestive protease-antiprotease pathway has lent additional support to the notion that pancreatitis is a disease of autodigestion. Clinical and experimental observations have provided compelling evidence that premature intrapancreatic activation of digestive proteases is critical in pancreatitis onset ...[more]