Unknown

Dataset Information

0

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.

ABSTRACT: Plasma cells (PC) are found in the CNS of multiple sclerosis (MS) patients, yet their source and role in MS remains unclear. We find that some PC in the CNS of mice with experimental autoimmune encephalomyelitis (EAE) originate in the gut and produce immunoglobulin A (IgA). Moreover, we show that IgA+ PC are dramatically reduced in the gut during EAE, and likewise, a reduction in IgA-bound fecal bacteria is seen in MS patients during disease relapse. Removal of plasmablast (PB) plus PC resulted in exacerbated EAE that was normalized by the introduction of gut-derived IgA+ PC. Furthermore, mice with an over-abundance of IgA+ PB and/or PC were specifically resistant to the effector stage of EAE, and expression of interleukin (IL)-10 by PB plus PC was necessary and sufficient to confer resistance. Our data show that IgA+ PB and/or PC mobilized from the gut play an unexpected role in suppressing neuroinflammation.

SUBMITTER: Rojas OL 

PROVIDER: S-EPMC6903689 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.

Rojas Olga L OL   Pröbstel Anne-Katrin AK   Porfilio Elisa A EA   Wang Angela A AA   Charabati Marc M   Sun Tian T   Lee Dennis S W DSW   Galicia Georgina G   Ramaglia Valeria V   Ward Lesley A LA   Leung Leslie Y T LYT   Najafi Ghazal G   Khaleghi Khashayar K   Garcillán Beatriz B   Li Angela A   Besla Rickvinder R   Naouar Ikbel I   Cao Eric Y EY   Chiaranunt Pailin P   Burrows Kyle K   Robinson Hannah G HG   Allanach Jessica R JR   Yam Jennifer J   Luck Helen H   Campbell Daniel J DJ   Allman David D   Brooks David G DG   Tomura Michio M   Baumann Ryan R   Zamvil Scott S SS   Bar-Or Amit A   Horwitz Marc S MS   Winer Daniel A DA   Mortha Arthur A   Mackay Fabienne F   Prat Alexandre A   Osborne Lisa C LC   Robbins Clinton C   Baranzini Sergio E SE   Gommerman Jennifer L JL  

Cell 20190103 3

Plasma cells (PC) are found in the CNS of multiple sclerosis (MS) patients, yet their source and role in MS remains unclear. We find that some PC in the CNS of mice with experimental autoimmune encephalomyelitis (EAE) originate in the gut and produce immunoglobulin A (IgA). Moreover, we show that IgA<sup>+</sup> PC are dramatically reduced in the gut during EAE, and likewise, a reduction in IgA-bound fecal bacteria is seen in MS patients during disease relapse. Removal of plasmablast (PB) plus P  ...[more]

Similar Datasets

Unknown Conventional CD4+ T cells regulate IL-22-producing intestinal innate lymphoid cells.
| S-EPMC4107180 | biostudies-literature
Unknown Intestinal barrier regulates immune responses in the liver via IL-10-producing macrophages.
| S-EPMC6124432 | biostudies-literature
Unknown Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist.
| S-EPMC4821642 | biostudies-literature
Unknown IL-10-producing CD4(+) T cells negatively regulate fucosylation of epithelial cells in the gut.
| S-EPMC4629126 | biostudies-literature
Unknown IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis.
| S-EPMC4428691 | biostudies-literature
Unknown MSC-like cells increase ability of monocyte-derived dendritic cells to polarize IL-17-/IL-10-producing T cells via CTLA-4.
| S-EPMC8027231 | biostudies-literature
Unknown IL-27-producing B-1a cells suppress neuroinflammation and CNS autoimmune diseases.
| S-EPMC8617509 | biostudies-literature
Unknown Regulatory roles of IL-10-producing human follicular T cells.
| S-EPMC6683995 | biostudies-literature
Unknown IL-10-producing regulatory cells impact on celiac disease evolution.
| S-EPMC10905269 | biostudies-literature
Unknown OX40 ligand shuts down IL-10-producing regulatory T cells.
| S-EPMC1559766 | biostudies-literature