Ontology highlight
ABSTRACT:
SUBMITTER: Gaylo-Moynihan A
PROVIDER: S-EPMC6904228 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Immunity 20190806 2
T-helper (Th) cell differentiation drives specialized gene programs that dictate effector T cell function at sites of infection. Here, we have shown Th cell differentiation also imposes discrete motility gene programs that shape Th1 and Th2 cell navigation of the inflamed dermis. Th1 cells scanned a smaller tissue area in a G protein-coupled receptor (GPCR) and chemokine-dependent fashion, while Th2 cells scanned a larger tissue area independent of GPCR signals. Differential chemokine reliance f ...[more]