Dataset Information

Association between fluoride exposure and cardiometabolic risk in peripubertal Mexican children.

ABSTRACT:

Background

Several animal studies have suggested that fluoride exposure may increase the levels of cardiometabolic risk factors, but little is known about whether fluoride exposure is associated with such risk in humans.

Objectives

We examined the cross-sectional association between peripubertal exposure to fluoride and markers of cardiometabolic risk in 280 girls and 256 boys at age 10-18?years living in Mexico City.

Methods

We measured plasma fluoride concentration using a microdiffusion method. We collected data on anthropometry including BMI, waist circumference (WC) and trunk fat percentage. We measured serum markers of cardiometabolic risk, including fasting glucose, insulin and lipids. All the indicators of outcome were converted to age- and sex-specific z-scores. We also calculated a summary cardiometabolic risk score for each participant. Multivariable linear regression models were used to examine these associations.

Results

The geometric mean (95% confidence interval (CI)) of plasma fluoride was 0.21??mol/L (0.20, 0.23??mol/L) in the total sample. In girls, plasma fluoride concentrations were associated with higher z-scores for all the individual markers (except for lipids) and for the combined cardiometabolic risk score (risk score: ??=?1.28, 95% CI: 0.57-2.00, p-sex interaction?=?0.02)), adjusting for covariates. No associations were found in boys.

Conclusions

We found that higher peripubertal fluoride exposure at the levels observed in this study population was significantly associated with increased levels of cardiometabolic risk factors in Mexican girls but not boys. Future studies with a longitudinal design are needed to confirm our findings and further elucidate the role of fluoride in cardiometabolic risk.

SUBMITTER: Liu Y

PROVIDER: S-EPMC6904509 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Publications

Association between fluoride exposure and cardiometabolic risk in peripubertal Mexican children.

Liu Yun Y Téllez-Rojo Martha M Sánchez Brisa N BN Ettinger Adrienne S AS Osorio-Yáñez Citlalli C Solano Maritsa M Hu Howard H Peterson Karen E KE

Environment international 20191111

<h4>Background</h4>Several animal studies have suggested that fluoride exposure may increase the levels of cardiometabolic risk factors, but little is known about whether fluoride exposure is associated with such risk in humans.<h4>Objectives</h4>We examined the cross-sectional association between peripubertal exposure to fluoride and markers of cardiometabolic risk in 280 girls and 256 boys at age 10-18 years living in Mexico City.<h4>Methods</h4>We measured plasma fluoride concentration using ...[more]

PMID: 31726363

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Project description:OBJECTIVES:While studies exist on the association between screen time and cardiometabolic risk among adolescents, research examining the effect of screen time on cardiometabolic risk in young children is lacking. The primary objective of this study was to examine the association between daily screen time and cardiometabolic risk (CMR) [sum of age- and sex-standardized z-scores of systolic blood pressure (SBP), glucose, log-triglycerides, waist circumference (WC), and negative high-density lipoprotein (HDL) cholesterol divided by the square root of five] in young children. Secondary objectives included examining individual CMR risk factors, including waist-to-height ratio and non high-density lipoprotein (non-HDL) cholesterol, as well as the individual cut-offs of these risk factors. Additional analyses include examining the association between screen time and CMR by handheld/non-handheld devices. METHODS:A study was conducted among young children 3 to 6?years from the TARGet Kids! practice-based research network in Toronto and Montreal, Canada. Children with one or more measures of screen time and CMR were included in this study. Generalized estimating equation (GEE) multivariable linear regressions and multivariable logistic regressions, using published cut-offs, were conducted to evaluate these associations. RESULTS:Data from 1317 children [mean age 52?months (SD?=?13.36), 44.34% female] were included for analyses. There was no evidence of associations between screen time and total CMR score or individual risk factors (p?>?0.05) after adjusting for confounders. A statistically significant, but small association between daily screen time and non-HDL cholesterol was found (B?=?0.046; CI?=?[0.017 to 0.075]; p?=?0.002. CONCLUSIONS:Though no relationship was reported between daily screen time and the majority of CMR factors in early childhood, there was an association between daily screen time and non-HDL cholesterol. As the relationship between daily screen time and CMR factors may not be apparent in early childhood, studies to evaluate longer-term cardiometabolic effects of screen time are needed. Although there is an evidence-based rationale to reduce screen time in early childhood, prevention of cardiometabolic risk may not be the primary driver.

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Dataset Information

Association between fluoride exposure and cardiometabolic risk in peripubertal Mexican children.

Background

Objectives

Methods

Results

Conclusions

Publications

Association between fluoride exposure and cardiometabolic risk in peripubertal Mexican children.

Similar Datasets

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