Ontology highlight
ABSTRACT:
SUBMITTER: Sariyer IK
PROVIDER: S-EPMC6904669 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Sariyer Ilker Kudret IK Gordon Jennifer J Burdo Tricia H TH Wollebo Hassen S HS Gianti Eleonora E Donadoni Martina M Bellizzi Anna A Cicalese Stephanie S Loomis Regina R Robinson Jake A JA Carnevale Vincenzo V Steiner Joseph J Ozdener Mehmet H MH Miller Andrew D AD Amini Shohreh S Klein Michael L ML Khalili Kamel K
Molecular therapy : the journal of the American Society of Gene Therapy 20191011 12
Zika virus (ZIKV) infection is associated with microcephaly in neonates and Guillain-Barré syndrome in adults. ZIKV produces a class of nonstructural (NS) regulatory proteins that play a critical role in viral transcription and replication, including NS5, which possesses RNA-dependent RNA polymerase (RdRp) activity. Here we demonstrate that rilpivirine (RPV), a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1 infection, inhibits the enzymatic activity of NS5 ...[more]