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Macrophage Mannose Receptor CD206 Predicts Prognosis in Community-acquired Pneumonia.

ABSTRACT: CD206, a mannose receptor, is mainly expressed on the surface of alternatively activated macrophages where it acts as a pattern recognition receptor and plays a role in innate and adaptive immunity. This study investigated serum soluble CD206 (sCD206) levels in community-acquired pneumonia (CAP) and examined their clinical significance. sCD206 concentrations were measured in the sera of two independent cohorts with CAP (127 and 125 patients, respectively) and 42 controls. The expression of CD206 in the lung from autopsied cases was also examined. Patients with CAP showed significantly elevated sCD206 levels than did the controls (p?+ macrophages was found in the lungs of fatal cases. Elevated levels of sCD206 are associated with CAP prognosis, suggesting sCD206 might be a potential biomarker to predict severity for CAP.

SUBMITTER: Tsuchiya K

PROVIDER: S-EPMC6904766 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Macrophage Mannose Receptor CD206 Predicts Prognosis in Community-acquired Pneumonia.

Tsuchiya Kazuo K Suzuki Yuzo Y Yoshimura Katsuhiro K Yasui Hideki H Karayama Masato M Hozumi Hironao H Furuhashi Kazuki K Enomoto Noriyuki N Fujisawa Tomoyuki T Nakamura Yutaro Y Inui Naoki N Yokomura Koushi K Suda Takafumi T

Scientific reports 20191210 1

CD206, a mannose receptor, is mainly expressed on the surface of alternatively activated macrophages where it acts as a pattern recognition receptor and plays a role in innate and adaptive immunity. This study investigated serum soluble CD206 (sCD206) levels in community-acquired pneumonia (CAP) and examined their clinical significance. sCD206 concentrations were measured in the sera of two independent cohorts with CAP (127 and 125 patients, respectively) and 42 controls. The expression of CD206 ...[more]

PMID: 31822747

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