Ontology highlight
ABSTRACT:
SUBMITTER: Izco M
PROVIDER: S-EPMC6904801 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Izco María M Blesa Javier J Schleef Martin M Schmeer Marco M Porcari Riccardo R Al-Shawi Raya R Ellmerich Stephan S de Toro María M Gardiner Chris C Seow Yiqi Y Reinares-Sebastian Alejandro A Forcen Raquel R Simons J Paul JP Bellotti Vittorio V Cooper J Mark JM Alvarez-Erviti Lydia L
Molecular therapy : the journal of the American Society of Gene Therapy 20190827 12
The development of new therapies to slow down or halt the progression of Parkinson's disease is a health care priority. A key pathological feature is the presence of alpha-synuclein aggregates, and there is increasing evidence that alpha-synuclein propagation plays a central role in disease progression. Consequently, the downregulation of alpha-synuclein is a potential therapeutic target. As a chronic disease, the ideal treatment will be minimally invasive and effective in the long-term. Knockdo ...[more]