Ontology highlight
ABSTRACT:
SUBMITTER: O'Neill BK
PROVIDER: S-EPMC6905437 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
ACS chemical biology 20180502 5
Technologies for measuring the transient Ca<sup>2+</sup> spikes that accompany neural signaling have revolutionized our understanding of the brain. Nevertheless, microscopic visualization of Ca<sup>2+</sup> spikes on the time scale of neural activity across large brain regions or in thick specimens remains a significant challenge. The recent development of stable integrators of Ca<sup>2+</sup>, instead of transient reporters, provides an avenue to investigate neural signaling in otherwise challe ...[more]