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Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues.

ABSTRACT: Several experimental and clinical studies have transformed the traditional antimalarial role of chloroquine (CHQ) and related structural analogues to potent therapeutic agents for a host of nonmalarial indications. The expanding clinical applicability for these drugs includes rheumatological and cardiovascular disorders (CVD), chronic kidney disease (CKD), oncology, and a variety of nonmalarial infections. These clinical advancements are primarily related to pleiotropic pharmacological actions of these drugs, including immunomodulation, anti-inflammatory properties, and capabilities of inducing autophagy and apoptosis at a cellular level. Historically, many clinical benefits in nonmalarial indications were first recognized through serendipitous observations; however, with numerous ongoing systematic clinical studies, the clinical horizons of these drugs have a promising future.

SUBMITTER: Shukla AM

PROVIDER: S-EPMC6905642 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues.

Shukla Ashutosh M AM Wagle Shukla Aparna A

Drugs in context 20191125

Several experimental and clinical studies have transformed the traditional antimalarial role of chloroquine (CHQ) and related structural analogues to potent therapeutic agents for a host of nonmalarial indications. The expanding clinical applicability for these drugs includes rheumatological and cardiovascular disorders (CVD), chronic kidney disease (CKD), oncology, and a variety of nonmalarial infections. These clinical advancements are primarily related to pleiotropic pharmacological actions o ...[more]

PMID: 31844421

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