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Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues.


ABSTRACT: Several experimental and clinical studies have transformed the traditional antimalarial role of chloroquine (CHQ) and related structural analogues to potent therapeutic agents for a host of nonmalarial indications. The expanding clinical applicability for these drugs includes rheumatological and cardiovascular disorders (CVD), chronic kidney disease (CKD), oncology, and a variety of nonmalarial infections. These clinical advancements are primarily related to pleiotropic pharmacological actions of these drugs, including immunomodulation, anti-inflammatory properties, and capabilities of inducing autophagy and apoptosis at a cellular level. Historically, many clinical benefits in nonmalarial indications were first recognized through serendipitous observations; however, with numerous ongoing systematic clinical studies, the clinical horizons of these drugs have a promising future.

SUBMITTER: Shukla AM 

PROVIDER: S-EPMC6905642 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues.

Shukla Ashutosh M AM   Wagle Shukla Aparna A  

Drugs in context 20191125


Several experimental and clinical studies have transformed the traditional antimalarial role of chloroquine (CHQ) and related structural analogues to potent therapeutic agents for a host of nonmalarial indications. The expanding clinical applicability for these drugs includes rheumatological and cardiovascular disorders (CVD), chronic kidney disease (CKD), oncology, and a variety of nonmalarial infections. These clinical advancements are primarily related to pleiotropic pharmacological actions o  ...[more]

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