Ontology highlight
ABSTRACT:
SUBMITTER: Hogan T
PROVIDER: S-EPMC6905650 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
eLife 20191119
Laboratory mice develop populations of circulating memory CD4<sup>+</sup> T cells in the absence of overt infection. We have previously shown that these populations are replenished from naive precursors at high levels throughout life (Gossel et al., 2017). However, the nature, relative importance and timing of the forces generating these cells remain unclear. Here, we tracked the generation of memory CD4<sup>+</sup> T cell subsets in mice housed in facilities differing in their 'dirtiness'. We f ...[more]