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Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer's dementia.

ABSTRACT: Sleep disruption is associated with cognitive decline and dementia in older adults; however, the underlying mechanisms are unclear. In rodents, sleep disruption causes microglial activation, inhibition of which improves cognition. However, data from humans are lacking. We studied participants in two cohort studies of older persons-the Rush Memory and Aging Project and the Religious Orders Study. We assessed sleep fragmentation by actigraphy and related this to cognitive function, to neocortical microglial marker gene expression measured by RNA sequencing, and to the neocortical density of microglia assessed by immunohistochemistry. Greater sleep fragmentation was associated with higher neocortical expression of genes characteristic of aged microglia, and a higher proportion of morphologically activated microglia, independent of chronological age- and dementia-related neuropathologies. Furthermore, these were, in turn, associated with worse cognition. This suggests that sleep fragmentation is accompanied by accelerated microglial aging and activation, which may partially underlie its association with cognitive impairment.

SUBMITTER: Kaneshwaran K

PROVIDER: S-EPMC6905859 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer's dementia.

Kaneshwaran Kirusanthy K Olah Marta M Tasaki Shinya S Yu Lei L Bradshaw Elizabeth M EM Schneider Julie A JA Buchman Aron S AS Bennett David A DA De Jager Philip L PL Lim Andrew S P ASP

Science advances 20191211 12

Sleep disruption is associated with cognitive decline and dementia in older adults; however, the underlying mechanisms are unclear. In rodents, sleep disruption causes microglial activation, inhibition of which improves cognition. However, data from humans are lacking. We studied participants in two cohort studies of older persons-the Rush Memory and Aging Project and the Religious Orders Study. We assessed sleep fragmentation by actigraphy and related this to cognitive function, to neocortical ...[more]

PMID: 31844665

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Dataset Information

Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer's dementia.

Publications

Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer's dementia.

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