Ontology highlight
ABSTRACT:
SUBMITTER: Gamiz-Arco G
PROVIDER: S-EPMC6906118 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Gamiz-Arco Gloria G Risso Valeria A VA Candel Adela M AM Inglés-Prieto Alvaro A Romero-Romero Maria L ML Gaucher Eric A EA Gavira Jose A JA Ibarra-Molero Beatriz B Sanchez-Ruiz Jose M JM
The Biochemical journal 20191201 23
Evolution involves not only adaptation, but also the degradation of superfluous features. Many examples of degradation at the morphological level are known (vestigial organs, for instance). However, the impact of degradation on molecular evolution has been rarely addressed. Thioredoxins serve as general oxidoreductases in all cells. Here, we report extensive mutational analyses on the folding of modern and resurrected ancestral bacterial thioredoxins. Contrary to claims from recent literature, i ...[more]