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Anti-IL-12/23p40 antibodies for maintenance of remission in Crohn's disease.

ABSTRACT:

SUBMITTER: Davies SC

PROVIDER: S-EPMC6906134 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Anti-IL-12/23p40 antibodies for maintenance of remission in Crohn's disease.

Davies Sarah C SC Nguyen Tran M TM Parker Claire E CE MacDonald John K JK Jairath Vipul V Khanna Reena R

The Cochrane database of systematic reviews 20191212

<h4>Background</h4>Ustekinumab and briakinumab are monoclonal antibodies that target the standard p40 subunit of cytokines interleukin-12 and interleukin-23 (IL-12/23p40), which are involved in the pathogenesis of Crohn's disease (CD). A significant proportion of people with Crohn's disease fail conventional therapy or therapy with biologics (e.g. infliximab) or develop significant adverse events. Anti-IL-12/23p40 antibodies such as ustekinumab may be an effective alternative for these individua ...[more]

PMID: 31828765

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