Ontology highlight
ABSTRACT:
SUBMITTER: Landry AP
PROVIDER: S-EPMC6906606 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Landry Aaron P AP Moon Sojin S Kim Hanseong H Yadav Pramod K PK Guha Arkajit A Cho Uhn-Soo US Banerjee Ruma R
Cell chemical biology 20191004 11
Mitochondrial sulfide quinone oxidoreductase (SQR) catalyzes the oxidation of H<sub>2</sub>S to glutathione persulfide with concomitant reduction of CoQ<sub>10</sub>. We report herein that the promiscuous activity of human SQR supported the conversion of CoA to CoA-SSH (CoA-persulfide), a potent inhibitor of butyryl-CoA dehydrogenase, and revealed a molecular link between sulfide and butyrate metabolism, which are known to interact. Three different CoQ<sub>1</sub>-bound crystal structures furnis ...[more]