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Runaway Kaposi Sarcoma-associated herpesvirus replication correlates with systemic IL-10 levels.


ABSTRACT: KSHV-associated inflammatory cytokine syndrome (KICS) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV). KICS is associated with high-level, systemic replication of KSHV. This study characterized the clinical and virologic features of a KICS patient over time. Additionally, it compared the cytokine profiles of the KICS case to Kaposi's sarcoma (KS) (n?=?11) and non-KS (n?=?6) cases. This KICS case presented with elevated levels of KSHV and IL-10, as expected. Surprisingly, this case did not have elevated levels of IL-6 or human immunodeficiency virus 1 (HIV-1). Nevertheless, treatment with anti-IL6 receptor antibody (tocilizumab) reduced KSHV viral load and IL-10. The KSHV genome sequence showed no significant changes over time, except in ORF24. Phylogenetic analysis established this isolate as belonging to KSHV clade A and closely related to other US isolates. These findings suggest IL-10 as potential biomarker and therapy target for KICS.

SUBMITTER: Caro-Vegas C 

PROVIDER: S-EPMC6908428 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Runaway Kaposi Sarcoma-associated herpesvirus replication correlates with systemic IL-10 levels.

Caro-Vegas Carolina C   Sellers Subhashini S   Host Kurtis M KM   Seltzer Jedediah J   Landis Justin J   Fischer William A WA   Damania Blossom B   Dittmer Dirk P DP  

Virology 20191002


KSHV-associated inflammatory cytokine syndrome (KICS) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV). KICS is associated with high-level, systemic replication of KSHV. This study characterized the clinical and virologic features of a KICS patient over time. Additionally, it compared the cytokine profiles of the KICS case to Kaposi's sarcoma (KS) (n = 11) and non-KS (n = 6) cases. This KICS case presented with elevated levels of KSHV and IL-10, as expected. Surprisingly, this case di  ...[more]

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