Ontology highlight
ABSTRACT:
SUBMITTER: Smith KM
PROVIDER: S-EPMC6908433 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Smith Kelly M KM Browne Tyler J TJ Davis Olivia C OC Coyle A A Boyle Kieran A KA Watanabe Masahiko M Dickinson Sally A SA Iredale Jacqueline A JA Gradwell Mark A MA Jobling Phillip P Callister Robert J RJ Dayas Christopher V CV Hughes David I DI Graham Brett A BA
eLife 20191112
Nociceptive information is relayed through the spinal cord dorsal horn, a critical area in sensory processing. The neuronal circuits in this region that underpin sensory perception must be clarified to better understand how dysfunction can lead to pathological pain. This study used an optogenetic approach to selectively activate spinal interneurons that express the calcium-binding protein calretinin (CR). We show that these interneurons form an interconnected network that can initiate and sustai ...[more]