Ontology highlight
ABSTRACT:
SUBMITTER: Auxerre-Plantie E
PROVIDER: S-EPMC6908436 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Auxerre-Plantié Emilie E Nakamori Masayuki M Renaud Yoan Y Huguet Aline A Choquet Caroline C Dondi Cristiana C Miquerol Lucile L Takahashi Masanori P MP Gourdon Geneviève G Junion Guillaume G Jagla Teresa T Zmojdzian Monika M Jagla Krzysztof K
eLife 20191212
Cardiac conduction defects decrease life expectancy in myotonic dystrophy type 1 (DM1), a CTG repeat disorder involving misbalance between two RNA binding factors, MBNL1 and CELF1. However, how DM1 condition translates into conduction disorders remains poorly understood. Here we simulated MBNL1 and CELF1 misbalance in the <i>Drosophila</i> heart and performed TU-tagging-based RNAseq of cardiac cells. We detected deregulations of several genes controlling cellular calcium levels, including increa ...[more]