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ABSTRACT: Background
Patients with chest pain and no obstructive coronary artery disease have shown a high incidence of major adverse cardiovascular events (MACE). We evaluated the role of absolute myocardial perfusion quantification in predicting all-cause mortality and MACE during long-term follow-up in this group of patients.Methods
We studied 79 patients who underwent Nitrogen-13 ammonia PET for quantification of global myocardial blood flow (MBF) and myocardial flow reserve (MFR) due to suspected impaired myocardial perfusion. Patients with coronary artery disease (i.e.,?>?30% stenosis in one or more coronary arteries) were excluded. We assessed all-cause mortality and MACE. MACE was defined as the composite incidence of death, myocardial infarction (MI), or hospitalization due to heart failure.Results
Median follow-up was 8 (IQR: 3-14) years. Univariate Cox regression showed that only MFR (P?=?0.01) was a predictor of all-cause mortality. Univariate Cox regression analysis showed that both MFR and Stress MBF were predictors of the composite endpoint of MACE (P?ConclusionQuantitative assessment of myocardial perfusion may predict all-cause mortality and MACE in patients with chest pain and normal coronary arteries in the long-term follow-up.
SUBMITTER: Monroy-Gonzalez AG
PROVIDER: S-EPMC6908551 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Monroy-Gonzalez Andrea G AG Tio R A RA de Groot J C JC Boersma H H HH Prakken N H NH De Jongste M J L MJL Alexanderson-Rosas E E Slart R H J A RHJA
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20181004 6
<h4>Background</h4>Patients with chest pain and no obstructive coronary artery disease have shown a high incidence of major adverse cardiovascular events (MACE). We evaluated the role of absolute myocardial perfusion quantification in predicting all-cause mortality and MACE during long-term follow-up in this group of patients.<h4>Methods</h4>We studied 79 patients who underwent Nitrogen-13 ammonia PET for quantification of global myocardial blood flow (MBF) and myocardial flow reserve (MFR) due ...[more]