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Long-term prognostic value of quantitative myocardial perfusion in patients with chest pain and normal coronary arteries.


ABSTRACT:

Background

Patients with chest pain and no obstructive coronary artery disease have shown a high incidence of major adverse cardiovascular events (MACE). We evaluated the role of absolute myocardial perfusion quantification in predicting all-cause mortality and MACE during long-term follow-up in this group of patients.

Methods

We studied 79 patients who underwent Nitrogen-13 ammonia PET for quantification of global myocardial blood flow (MBF) and myocardial flow reserve (MFR) due to suspected impaired myocardial perfusion. Patients with coronary artery disease (i.e.,?>?30% stenosis in one or more coronary arteries) were excluded. We assessed all-cause mortality and MACE. MACE was defined as the composite incidence of death, myocardial infarction (MI), or hospitalization due to heart failure.

Results

Median follow-up was 8 (IQR: 3-14) years. Univariate Cox regression showed that only MFR (P?=?0.01) was a predictor of all-cause mortality. Univariate Cox regression analysis showed that both MFR and Stress MBF were predictors of the composite endpoint of MACE (P?ConclusionQuantitative assessment of myocardial perfusion may predict all-cause mortality and MACE in patients with chest pain and normal coronary arteries in the long-term follow-up.

SUBMITTER: Monroy-Gonzalez AG 

PROVIDER: S-EPMC6908551 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Long-term prognostic value of quantitative myocardial perfusion in patients with chest pain and normal coronary arteries.

Monroy-Gonzalez Andrea G AG   Tio R A RA   de Groot J C JC   Boersma H H HH   Prakken N H NH   De Jongste M J L MJL   Alexanderson-Rosas E E   Slart R H J A RHJA  

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20181004 6


<h4>Background</h4>Patients with chest pain and no obstructive coronary artery disease have shown a high incidence of major adverse cardiovascular events (MACE). We evaluated the role of absolute myocardial perfusion quantification in predicting all-cause mortality and MACE during long-term follow-up in this group of patients.<h4>Methods</h4>We studied 79 patients who underwent Nitrogen-13 ammonia PET for quantification of global myocardial blood flow (MBF) and myocardial flow reserve (MFR) due  ...[more]

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