Ontology highlight
ABSTRACT:
SUBMITTER: Shan C
PROVIDER: S-EPMC6908683 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Shan Chao C Xie Xuping X Luo Huanle H Muruato Antonio E AE Liu Yang Y Wakamiya Maki M La Jun-Ho JH Chung Jin Mo JM Weaver Scott C SC Wang Tian T Shi Pei-Yong PY
Nature communications 20191212 1
An important goal of the Zika virus (ZIKV) vaccine is to prevent a congenital syndrome in fetuses of pregnant women, but studies directly evaluating maternal vaccination for ZIKV are lacking. Here we report maternal vaccination using a live-attenuated ZIKV vaccine (3'UTR-∆10-LAV) in a pregnant mouse model. Maternal immunization with 3'UTR-∆10-LAV does not cause any adverse effects on pregnancy, fetal development, or offspring behavior. One maternal immunization fully protects dams against ZIKV i ...[more]