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Kalshiolin A, new lignan from Kalimeris shimadai.

ABSTRACT: The Asian plant Kalimeris shimadai has been used as food and ethnologic medicine for over a thousand years. In this study, we isolated and identified one new lignan, kalshiolin A (1), and 12 known lignans (2-13). The structures were characterized by the comprehensive analyses of spectroscopic data (HR-ESI-MS, IR, 1D, and 2D-NMR) and the absolute configuration of 1 was determined from ECD calculations. The new compound 1 was also screened for cytotoxic activity but did not show significant potency (IC50 35.9-43.3 μM) against A549, MDA-MB-231, MCF7, KB, and KB-VIN cell lines.

SUBMITTER: Wang GK 

PROVIDER: S-EPMC6908768 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Kalshiolin A, new lignan from <i>Kalimeris shimadai</i>.

Wang Guo-Kai GK   Jin Wen-Fang WF   Zhang Nan N   Wang Gang G   Cheng Yung-Yi YY   Morris-Natschke Susan L SL   Goto Masuo M   Zhou Zhong-Yu ZY   Liu Jin-Song JS   Lee Kuo-Hsiung KH  

Journal of Asian natural products research 20190613 5

The Asian plant <i>Kalimeris shimadai</i> has been used as food and ethnologic medicine for over a thousand years. In this study, we isolated and identified one new lignan, kalshiolin A (<b>1</b>), and 12 known lignans (<b>2-13</b>). The structures were characterized by the comprehensive analyses of spectroscopic data (HR-ESI-MS, IR, 1D, and 2D-NMR) and the absolute configuration of <b>1</b> was determined from ECD calculations. The new compound <b>1</b> was also screened for cytotoxic activity  ...[more]