Ontology highlight
ABSTRACT:
SUBMITTER: Hogan MF
PROVIDER: S-EPMC6908819 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Hogan Meghan F MF Ziemann Mark M K N Harikrishnan H Rodriguez Hanah H Kaspi Antony A Esser Nathalie N Templin Andrew T AT El-Osta Assam A Kahn Steven E SE
Protein engineering, design & selection : PEDS 20191201 2
Aggregation of islet amyloid polypeptide (IAPP) into islet amyloid results in β-cell toxicity in human type 2 diabetes. To determine the effect of islet amyloid formation on gene expression, we performed ribonucleic acid (RNA) sequencing (RNA-seq) analysis using cultured islets from either wild-type mice (mIAPP), which are not amyloid prone, or mice that express human IAPP (hIAPP), which develop amyloid. Comparing mIAPP and hIAPP islets, 5025 genes were differentially regulated (2439 upregulated ...[more]