Ontology highlight
ABSTRACT:
SUBMITTER: van der Kant R
PROVIDER: S-EPMC6908821 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
van der Kant Rob R Bauer Joschka J Karow-Zwick Anne R AR Kube Sebastian S Garidel Patrick P Blech Michaela M Rousseau Frederic F Schymkowitz Joost J
Protein engineering, design & selection : PEDS 20191201 3
Monoclonal antibodies bind with high specificity to a wide range of diverse antigens, primarily mediated by their hypervariable complementarity determining regions (CDRs). The defined antigen binding loops are supported by the structurally conserved β-sandwich framework of the light chain (LC) and heavy chain (HC) variable regions. The LC genes are encoded by two separate loci, subdividing the entity of antibodies into kappa (LCκ) and lambda (LCλ) isotypes that exhibit distinct sequence and conf ...[more]